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Literature summary extracted from

  • Nitani, Y.; Satow, Y.; Adachi, H.; Tsujimoto, M.
    Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis (2002), J. Mol. Biol., 321, 177-184.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.13.19
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.19 Cilastatin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.13.19 membrane bound to Homo sapiens 16020
-
3.4.13.19 microvillus the active site faces towards the microvillar membrane of a kidney tubule Homo sapiens 5902
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.19 Zinc the active site in each of the (alpha/beta)8 barrel subunits of the homodimer molecule is composed of binuclear zinc ions bridged by the Glu125 side-chain located at the bottom of the barrel Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.13.19 additional information Homo sapiens the enzyme is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.19 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.13.19 glycoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.19 kidney tubule Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.19 additional information the enzyme is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics Homo sapiens ?
-
 ?